Analysis of individual cone-photoreceptor directionality using scanning laser ophthalmoscopy
نویسندگان
چکیده
Scanning laser ophthalmoscopy has been used to measure individual cone-photoreceptor directionalities in the living human eye. The directionality is determined at different retinal eccentricities where it is expected that cones have diameters ranging between 5-10μm, comparable to the spot size of the incident beam. Individual cone directionality values are compared with the predicted directionalities obtained by using the waveguide model of light coupling to and from photoreceptors for the case of a focused incident beam.
منابع مشابه
Ultrasmall spot size scanning laser ophthalmoscopy
An ultrasmall spot size scanning laser ophthalmoscope has been developed that employs an annular aberration-corrected incident beam to increase the effective numerical aperture of the eye thereby reducing the width of the probing light spot. Parafovea and foveal cone photoreceptor visibility determined from small area retinal image scans are discussed from the perspective of mode matching betwe...
متن کاملMacular Cone Abnormalities in Retinitis Pigmentosa with Preserved Central Vision Using Adaptive Optics Scanning Laser Ophthalmoscopy
PURPOSE To assess macular photoreceptor abnormalities in eyes with retinitis pigmentosa (RP) with preserved central vision using adaptive optics scanning laser ophthalmoscopy (AO-SLO). METHODS Fourteen eyes of 14 patients with RP (best-corrected visual acuity 20/20 or better) and 12 eyes of 12 volunteers underwent a full ophthalmologic examination, fundus autofluorescence, spectral-domain opt...
متن کاملNoninvasive imaging of the thirteen-lined ground squirrel photoreceptor mosaic.
Ground squirrels are an increasingly important model for studying visual processing, retinal circuitry, and cone photoreceptor function. Here, we demonstrate that the photoreceptor mosaic can be longitudinally imaged noninvasively in the 13-lined ground squirrel (Ictidomys tridecemlineatus) using confocal and nonconfocal split-detection adaptive optics scanning ophthalmoscopy using 790 nm light...
متن کاملIn vivo analysis of cone survival in mice.
PURPOSE To identify individual cone photoreceptors in a transgenic mouse line in vivo based on selective expression of green fluorescent protein (GFP) using cSLO (confocal scanning laser ophthalmoscopy) and to use this approach to monitor cone cell fate in mouse models of retinal degeneration. METHODS Transgenic mice expressing GFP under the control of a red-green opsin promoter (RG-GFP mice)...
متن کاملCone and rod loss in Stargardt disease revealed by adaptive optics scanning light ophthalmoscopy.
IMPORTANCE Stargardt disease (STGD1) is characterized by macular atrophy and flecks in the retinal pigment epithelium. The causative ABCA4 gene encodes a protein localizing to photoreceptor outer segments. The pathologic steps by which ABCA4 mutations lead to clinically detectable retinal pigment epithelium changes remain unclear. We investigated early STGD1 using adaptive optics scanning light...
متن کامل